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Low Blood Sugar May Affect Heartbeat in People With Diabetes

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Apr
23

TUESDAY, April 22, 2014 (HealthDay News) — Low blood sugar levels — known as hypoglycemia — in people with diabetes may cause potentially dangerous changes in heart rate, according to a small new study.

This study’s findings may help explain why a large-scale study found that very tight control of blood sugar levels in people with type 2 diabetes led to higher-than-expected death rates. It may also help explain why some otherwise healthy people with type 1 diabetes die during their sleep — sometimes called “dead-in-bed syndrome” — without an apparent cause, researchers say.

“We found that hypoglycemia was fairly common and that nocturnal episodes in particular were generally marked by a pattern whereby glucose levels dropped to low levels for some hours during which patients slept,” said Dr. Simon Heller, senior study author and a professor of clinical diabetes and honorary consultant physician at the University of Sheffield, in England.

“These periods of hypoglycemia were associated with a high risk of marked slow heart rates [bradycardia] accompanied by [abnormal] beats. We have therefore identified a mechanism which might contribute to increased mortality in individuals with type 2 diabetes and high cardiovascular risk during intensive insulin therapy,” Heller said.

Low blood sugar levels are not uncommon in people with diabetes, a disease that can produce dangerously high blood sugar levels. That’s because the very treatments that can help prevent high blood sugar levels — and the serious complications that accompany long-term high blood sugar levels — can cause blood sugar levels to drop too low.

Although some oral diabetes medications can cause low blood sugar levels, the most common treatment to drop blood sugar levels too low is insulin. Insulin is a naturally occurring hormone that helps usher sugar into cells to be used as fuel.

“Your body needs fuel to survive and run properly,” said Dr. Simon Fisher, an associate professor of medicine, cell biology and physiology at Washington University in St. Louis. “During hypoglycemia, the body is low on energy. When hypoglycemia is more severe, the brain [which runs on sugar] can get confused and stop functioning. If the blood sugar gets low enough, hypoglycemia can be fatal.”

Fisher is also a co-author of an editorial accompanying the study in the May issue of Diabetes.

Low blood sugar is a well-recognized problem for people with type 1 diabetes, who must take multiple daily injections of insulin because their bodies no longer produce the hormone, according to study author Heller. But, low blood sugar generally isn’t considered to be as significant a problem in type 2 diabetes, noted Heller, who added that the researchers were somewhat surprised to see that people with type 2 diabetes had low blood sugar levels about 10 percent of the time.

The study included 25 people with type 2 diabetes who had a known risk of heart disease. Their average age was 64 years. They were all being treated with insulin, and had been on insulin therapy for at least four years.

All of the study volunteers were monitored with a continuous glucose monitor for five days, as well as a 12-lead Holter monitor that captured heart activity. Both of these devices are portable, which allowed the study volunteers to carry on with normal daily activities.

Overall, the researchers recorded 1,258 hours of time with normal blood sugar levels, 65 hours with high blood sugar levels and 134 hours of low blood sugar levels. Low blood sugar was defined as a blood sugar of less than 63 milligrams per deciliter. These low blood sugar levels often went unrecognized, according to the study.

The risk of a slow heart rate was eight times higher when blood sugar was low at night compared to when it was normal. Slow heart rates didn’t occur during the day, according to the study. Other types of abnormal heartbeats (arrhythmias) were also significantly higher at night when blood sugar was low compared to when blood sugar was normal. No irregular heartbeats occurred when low blood sugar symptoms were felt by the study participants.

“This study noted that spontaneous insulin-induced episodes of hypoglycemia were associated with asymptomatic mild heart arrhythmias. We have performed similar studies in animals, and noted similar arrhythmias during insulin-induced hypoglycemia,” Fisher said.

“However, in animal studies, when blood sugar became severely low, more severe abnormal cardiac rhythms — in other words, fatal heart rhythms — were noted. So, based on existing animal and human data, we speculate that severe hypoglycemia-induced arrhythmias may contribute to sudden death in patients with insulin-treated diabetes,” Fisher said.

He continued, “Nocturnal hypoglycemia is a major problem. People are less likely to wake up and treat their hypoglycemia at night. They’re less likely to appreciate the normal warning symptoms of hypoglycemia because the entire sympathetic response is relatively blunted at night.”

While the study found an association between low blood sugar levels and abnormal heart rhythms in people with type 2 diabetes, it did not prove a cause-and-effect relationship.

Another expert said the new findings highlight the dangers of hypoglycemia.

“This study suggests that the deeper the hypoglycemia, the more abnormal the heart rhythms. There seems to be some real scientific plausibility that recurrent episodes of hypoglycemia can cause abnormal disturbances of the heart. Each episode of hypoglycemia may have some element of risk,” said Dr. John Anderson, the immediate past president of the American Diabetes Association.

“It may be that tight control of blood sugar might not be as important as safe control of blood sugar. Avoiding severe hypoglycemia should be a primary goal of therapy, especially for those who have a lot of risk for heart disease. That’s why the American Diabetes Association said in 2012 that glycemic goals should be individualized. And, if you have to use insulin, avoiding those 3 a.m. hypoglycemias may be even more important,” Anderson said.

In addition to changing target blood sugar goals, Anderson and Fisher both said that the use of a continuous glucose monitor with alarms could also help people avoid low blood sugar levels in the middle of the night. “[Continuous glucose monitoring] isn’t thought of as much for the type 2 population. But, there are a lot of people with type 2 diabetes on insulin who have cardiovascular disease. This might be a prudent use of [continuous glucose monitoring],” Anderson said.

Fisher agreed, noting, “Technology — like [continuous glucose monitors] and insulin pumps — may be able to decrease the number of hypoglycemic episodes while still allowing patients to maintain tight glycemic control.”

More information

Learn more about hypoglycemia from the American Diabetes Association.

 

SOURCES: Simon Heller, M.D., professor of clinical diabetes, and honorary consultant physician, University of Sheffield, England; John Anderson, M.D., immediate past president, American Diabetes Association; Simon Fisher, M.D., Ph.D., associate professor of medicine, cell biology and physiology, Washington University, St. Louis; May 2014, Diabetes

Copyright © 2014 HealthDay. All rights reserved.


Article source: http://www.philly.com/philly/health/diabetes/HealthDay687042_20140422_Low_Blood_Sugar_May_Affect_Heartbeat_in_People_With_Diabetes.html

False-positive Mammograms Increase Anxiety of Women

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Apr
23

False-positive Mammograms Increase Anxiety of Women

By Julie S | Apr 23, 2014 09:01 AM EDT


Mammogram



A new study found that women who receive false-positive mammogram results experience heightened anxiety. However, the results do not affect their willingness to have another screening after two years.

A false-positive result indicates that the person is a carrying a disease or condition when he does not have it. He may have tested positive during the initial test but came out negative after follow-up evaluations. While it is good news that the results are not positive, others do not appreciate it because they had to undergo unnecessary procedures that are just frustrating.

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According to the National Cancer Institute, 90 percent of the mammogram results give false-positive results. Follow-up evaluations after the initial screening are done such as ultrasound, magnetic resonance imaging, and tissue sampling to fully determine if the patient is clear from breast cancer.

Researchers from the Geisel School of Medicine at Dartmouth led by professor Anna Tosteson conducted a telephone survey on 1,226 randomly selected women with positive and negative results. These women were participants of the Digital Mammographic Imaging Screening Trial (DMIST). Almost half, or 494, of them received false-positive results.

The survey focused on determining the anxiety levels of the women who received false-positive results and finding out if they would still want to undergo screening in the next two years. After tabulating the responses, they found that 50.6 percent of these women experienced moderate to high levels of anxiety. They rated it to be an average of 4.6 percent higher after receiving the results.

Furthermore, 25.7 percent of the participants were not discouraged in subjecting themselves to another breast cancer screening in the next two years compared to 14.2 percent from those who received negative results.

“Our finding of time-limited harm after false-positive screening mammograms is relevant for clinicians who counsel women on mammographic screening and for screening guideline development groups,” the researchers wrote.

This study was published in the April 21 issue of the JAMA Internal Medicine.



Article source: http://www.hngn.com/articles/29491/20140423/false-positive-mammograms-increase-anxiety-of-women.htm

California Sees Rise in Whooping Cough Cases

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Apr
23

There’s a rise in the number of whooping cough cases in California.  

Dr. Mitchell Kushner says his Southern California practice is seeing a significant increase.

“Part of the problem, rather than just the immunization question, is that children are contagious, they’re going to school, and they’re spreading the illness,” Kushner said. 

In Long Beach alone, there have been more than 40 cases since the beginning of the year.  There were only 12 in all of 2013.

Health officials say other cities around California and the nation are seeing whooping cough increases, and they say its important that all age groups get immunized.

Article source: http://www.kfbk.com/articles/kfbk-news-461777/california-sees-rise-in-whooping-cough-12280542/

Saudi Arabia Reports 11 New MERS Cases as Virus Spreads to Mecca

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Apr
23

Saudi Arabia reported another 11
cases of a potentially deadly respiratory virus, including the
first in the Muslim holy city of Mecca.

Six of the people to have newly contracted Middle East
Respiratory Syndrome, or MERS, were in Jeddah, the kingdom’s
largest city with another four in the capital, Riyadh, and one
in Mecca, according to a health ministry statement. That brings
the total number of cases in the country to 272.

At least 93 have died of the disease since it emerged in
Saudi Arabia in September 2012, according to the World Health
Organization. MERS, which has been linked to contact with
camels, is in the same family as the SARS virus that killed
about 800 people worldwide after first appearing in China.

Saudi Arabia is consulting global experts from Germany,
France, the U.K. and the U.S. on how to combat the virus. The
kingdom removed Health Minister Abdullah al-Rabeeah from office
on April 21 as it moved to fight the outbreak, replacing him on
an acting basis with Labor Minister Adel Faqih.

“Every effort is being made to understand its current
behavior and any potential alteration in its behavior,”
Assistant Deputy Minister of Health Mohammed Zamakhshary said in
an interview of the coronavirus that causes the illness.

In Jordan, a 25-year-old Saudi citizen tested positive for
the disease and is in a stable condition, the state-run Petra
news agency said yesterday.

Zoonotic virus

“We believe MERS is a zoonotic virus, meaning that the
virus comes from animals, namely camels, and is transmitted to
humans,” said Maria Van Kerkhove, a senior research fellow at
Imperial College in London and a technical expert for the WHO.
“The virus can also be transmitted from human to human, which
we have seen between family members and health-care workers
caring for MERS patients.”

The virus has spread to Southeast Asia, killing a Malaysian
man who visited Saudi Arabia, the WHO said last week. A Filipino
health-care worker returning from Abu Dhabi who initially tested
positive for MERS was shown not to have the virus when a second
test was carried out.

Saudi Arabia expects millions of pilgrims from around the
world to perform the annual Haj in Mecca and Medina in early
October.

To contact the reporters on this story:
Deema Almashabi in Riyadh at
dalmashabi@bloomberg.net;
Kambiz Foroohar in New York at
kforoohar@bloomberg.net

To contact the editors responsible for this story:
Andrew J. Barden at
barden@bloomberg.net
Caroline Alexander, Mark Williams

Article source: http://www.businessweek.com/news/2014-04-22/saudi-arabia-seeks-outside-help-to-combat-deadly-mers-outbreak

Ebola outbreak: Death toll rises to over 140 in Liberia, Guinea

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Apr
23


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A Guinea-Bissau customs official watches arrivals from Conakry, the capital of Guinea, on Tuesday, April 8. Conakry is being ravaged by an Ebola virus epidemic, and Guinea-Bissau officials are concerned about a possible case inside their borders. A Guinea-Bissau customs official watches arrivals from Conakry, the capital of Guinea, on Tuesday, April 8. Conakry is being ravaged by an Ebola virus epidemic, and Guinea-Bissau officials are concerned about a possible case inside their borders.

Guinea-Bissau nurse Egidia Almeida scans a Guinean citizen coming from Conakry on April 8. Dozens of people have died from an Ebola outbreak in coastal West Africa, aid workers reported.Guinea-Bissau nurse Egidia Almeida scans a Guinean citizen coming from Conakry on April 8. Dozens of people have died from an Ebola outbreak in coastal West Africa, aid workers reported.

A scientist separates blood cells from plasma cells to isolate any Ebola RNA in order to test for the virus at the European Mobile Laboratory in Gueckedou, Guinea, near the borders of Sierra Leone and Liberia, on Thursday, April 3. Ebola is one of the world's deadliest viruses, causing a hemorrhagic fever that kills up to 90% of those infected. It spreads in the blood and shuts down the immune system, causing high fever, headache and muscle pain, often accompanied by bleeding.A scientist separates blood cells from plasma cells to isolate any Ebola RNA in order to test for the virus at the European Mobile Laboratory in Gueckedou, Guinea, near the borders of Sierra Leone and Liberia, on Thursday, April 3. Ebola is one of the world’s deadliest viruses, causing a hemorrhagic fever that kills up to 90% of those infected. It spreads in the blood and shuts down the immune system, causing high fever, headache and muscle pain, often accompanied by bleeding.

Members of the medical aid organization Medecins sans Frontieres carry a dead body in Gueckedou on Friday, April 1. Members of the medical aid organization Medecins sans Frontieres carry a dead body in Gueckedou on Friday, April 1.

Gloves and boots used by medical personnel dry in the sun April 1 outside a center for Ebola victims in Gueckedou. Gloves and boots used by medical personnel dry in the sun April 1 outside a center for Ebola victims in Gueckedou.

A health specialist works Monday, March 31, in a tent laboratory set up at a Medecins sans Frontieres facility in southern Guinea.A health specialist works Monday, March 31, in a tent laboratory set up at a Medecins sans Frontieres facility in southern Guinea.

Health specialists work March 31 at an isolation ward for patients at the facility in southern Guinea.Health specialists work March 31 at an isolation ward for patients at the facility in southern Guinea.

Workers associated with Medecins sans Frontieres prepare isolation and treatment areas Friday, March 28, in Guinea. Workers associated with Medecins sans Frontieres prepare isolation and treatment areas Friday, March 28, in Guinea.


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(CNN) — A total of 142 deaths have been reported from the Ebola outbreak in Guinea and Liberia, the World Health Organization said.


Dozens killed by ebola outbreak


Doctors work to isolate Ebola outbreak

The virus is still limited to the two nations, the World Health Organization said Tuesday, despite rumors of it spreading to other countries.

Nineteen suspected cases reported in Sierra Leone tested negative for the virus, it said.

In a statement on its website, WHO said Guinea has reported a total of 208 clinical cases of Ebola, including 136 deaths. Liberia has reported 34 cases, including six deaths.

Ebola is one of the world’s deadliest viruses and kills up to 90% of those infected. It spreads in the blood and shuts down the immune system, causing high fever, headache and muscle pain, often accompanied by bleeding.

It’s the first emergence of Ebola in western Africa, which means doctors and health officials in the region don’t have any experience with the virus.

The aid organization Doctors Without Borders has called the outbreak unprecedented because previous cases have been limited to a small area.

The virus is named after the Ebola River in the Democratic Republic of Congo.

We’re aliens in Ebola’s world

A swift, effective and bloody killer

Why does it kill?



Article source: http://www.cnn.com/2014/04/23/health/africa-ebola/

Bollywood stars head for IIFA

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Apr
23

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Obama arrives in Japan for first leg of tension-filled Asia trip

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Apr
23

Article source: http://timesofindia.indiatimes.com/world/rest-of-world/Obama-arrives-in-Japan-for-first-leg-of-tension-filled-Asia-trip/articleshow/34116855.cms

Yeh Hai Bakrapur

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Apr
23

Janaki Vishwanathan’s “Yeh Hai Bakrapur” is soon going to hit the theatres and the director says that the movie involved a lot of hard work, but it’s worth it as people have already shown support to the film.

Produced by Ramesh Sriivatsava Aruunachalam, the film is slated to release May 9.

The film’s romantic number “Pyaar mein bakra” was released here Monday and it received a positive response from the music lovers.

“‘Yeh Hai Bakrapur’ has been a labour of love, and the live response of the fans at the music launch just made all the hard work worth it. The movie has been getting widespread appreciation even before its release, and we can’t wait for film buffs to finally watch it on-screen,” Vishwanathan, known for her National Award winning film “Kutty” in Tamil, said in a statement.

Starring Anshuman Jha and Yoshika Verma, “Yeh Hai Bakrapur” is the story of Qureshi family and their pet goat Shahrukh, who acquires rock star status in his village and beyond.

Article source: http://www.pinkvilla.com/taxonomy/term/20134

IBNLive Movie Awards: ‘Goliyon Ki Rasleela – Ram Leela’ gets highest votes in …

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Apr
23

Production designing is one area of filmmaking that often goes unnoticed, but you can’t expect a good film without the help of this department. In response to IBNLive poll, the readers gave maximum votes 41.59% to Sanjay Leela Bhansali’s ‘Goliyon ki Rasleela – Ram Leela’. The majestic and grand sets in the film are the result of the sweat and blood of production designers. As is the case with all Sanjay Leela Bhansali movies, the work of a production designer is seen in each and every frame of the movie. The grandeur of Ram Leela made it the most popular movie in the category with a major share of 41.59% of the total votes.

From Farhan Akhtar’s wardrobe to the interior of the train, everything of ‘Bhaag Milkha Bhaag’ was touched up with perfection, which ultimately resulted into a believable film, even the background of the swimming pool was taken care of. The team of ‘Bhaag Milkha Bhaag’ put extra emphasis on getting the quintessential old Delhi charm right. Not at a single point in the film, the audience questioned the feel of the film. Rakeysh Omprakash Mehra’s film is the first nominee in this category. The film received 26.9% votes.

Why ‘Kai Po Che’? Simply because the whole canvas of the film kept changing at a rapid pace. Though the story was set mostly in one area, but the colourful backdrop of Gujarat had to be shown without getting into the eyes of the viewers. The story and the background were two different things for this film and the director and the production design team had to work in tandem to emerge victorious, which they eventually did. It earned 8.85%.

IBNLive Movie Awards: 'Goliyon Ki Rasleela - Ram Leela' gets highest votes in Best Production Design category

In response to IBNLive poll, the readers gave maximum votes 41.59% to ‘Goliyon ki Rasleela – Ram Leela’.

The story of ‘Raanjhanaa’ covered a time period of close to ten years which meant travelling of characters from one space to another quite frequently. The first part of the film was set in Benares and the second part was based in Delhi, with clear cut changes in the character graphs of lead actors. Every task related to a character’s dressing to his mode of travelling had to be performed twice to get it right. Thankfully, ‘Raanjhanaa’ emerged as a colourful and engaging film. About 15.93% votes went to the film.

Jaipur is popularly known as the pink city, but how would you show it on celluloid? In this case, the only person who can transform the director’s dream into reality is the person in-change of the production design team. Didn’t you like the final product of ‘Shuddh Desi Romance’? Of course, you did. ‘Shuddh Desi Romance’ is the final film in this list. Now, make your vote count. It earned 7% votes.


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Article source: http://ibnlive.in.com/news/ibnlive-movie-awards-goliyon-ki-rasleela--ram-leela-gets-highest-votes-in-best-production-design-category/467003-8-66.html

Setting a bad example: Cricketers and Bollywood stars to miss voting in Lok …

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Apr
23
  • Elections
    RNA Research Archives

The stage is set for India’s biggest political battle as the sixth phase of polling begins on Thursday.

Political bigwigs have upped the campaings and are seen on various platforms such as television, radio, newspapers and websites seeking votes. But, Bollywood and Cricket are two industries that will give a major miss to voting this year. 

While due to ongoing IPL matches, many cricketers will miss the elections, Bollywood’s extravagant award show IIFA will cause many stars to skip the voting process altogether. 

Over 814 million people will be eligible to vote in the 2014 elections, making it the biggest Lok Sabha polls — and the biggest democratic parliamentary elections anywhere in the world.
Bollywood and cricket are the biggest influencers for youth and also the highest revenue generating industries in India. Hence, it is important that these so called ‘icons’ participate in the electoral process. 

Many IPL players will miss out from participating in the elections as the first part of their on-going tournament has been shifted to United Arab Emirates. Similarly, IIFA will take place at Tampa Bay in United states and many stars are participating in numerous events. 

Indian team’s captain Mahendra Singh Dhoni will not be able to vote because Ranchi goes to polls on April 23.

The reason being his team Chennai Super Kings clashing with Delhi Daredevils in Durban at IPL session. 

“There is no provision for online voting in India,” said H. S. Brahma, one of the two Election Commissioners (the other being Dr. Nasim Zaidi) from New Delhi while explaining absence of online voting for stars to a news daily. 

Not only these stars but also their team owners such as Shah Rukh Khan, Priety Zinta, Shilpa Shetty may miss the elections due to ongoing tournaments. 

Virat Kohli was a part of awareness campaign for Delhi elections in 2013 and has been anointed as ambassador for elections to target new voters entering the election fray. 

But, due to IPL, even Virat may not be able to exercise the voting franchise. 

In terms of Bollywood, according to IIFA organisers, dates for the festival had been decided much in advance. Hence many stars are flying out of the country to perform at USA.  

Bollywood stars have been potraying roles of politicians, common man and activists in movies. Even in real life, they participate in candle-light vigil to show solidarity against crimes. So wouldn’t elections be the best way to bring reel to real life? 

While stars such as Salman Khan (his last film was Jai Ho which spoke about corruption), Deepika Padukone (She was born at Copenhagen), Sonakshi Sinha (Shatrugan Sinha is contesting in elections), Vivek Oberoi (His mother Priyanka Alva is contesting elections) and Priyanka Chopra will not be voting due to work commitments, many others have promised to vote. 

This list includes Ranbir Kapoor, Sonam Kapoor, Aamir Khan (Election commission’s ambassador) and veteran Amitabh Bachchan. 

Some of Bollywood’s prominent stars such as Nagma, Kirron Kher, Gul Panag and Javed Jafferi are contesting elections.

It is a matter of utmost disgrace that our cricketing icons and stars will not be voting in the democratic process as citizens of India.

Setting a bad example by taking elections for granted, these stars should not complain if there is any negative event that occurs after the new government comes in place. Because, if you don’t take one day out for your country, then even the right to complain about the system is automatically taken away. 

Youngsters should definitely vote and choose a government that they want to see at the helm of affairs. While they should definitely reassess their role-models who defy their duties to vote. In any democratic setup, every citizen has to vote. 

In countries like Australia, not participating in elections and voting can land you in legal trouble. But the rules are much lenient in India and hence people take advantage. 

Election Commission and the government have brought in NOTA (None of the above) option for individuals who prefer to reject all their candidates on any grounds. If this does not bring you the ballot office, we are not sure what will! 

Its your right to vote! To be participative and select the course of future for India. Sparing a day for your country is important and should be termed as a duty to be fulfilled. 

So, go ahead and be your own icon! Vote for a better India. 

 

Article source: http://www.dnaindia.com/india/report-setting-a-bad-example-cricketers-and-bollywood-stars-to-miss-voting-in-lok-sabha-elections-1981332

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